Company Moves into Industry’s Most Advanced Facility Providing Biotech-Grade Equipment and Implements Standardized Procedures to Enable New Generation of Care Beyond “Medical Marijuana”
RICHMOND, Calif., April 7, 2016 – Constance Therapeutics, a whole plant cannabis extract producer, is ushering a new era of care, Care 2.0, in which whole plant cannabis extracts are integrated into traditional healthcare to provide physicians and their patients with additional treatment options. Care 2.0 is enabled by an entirely new category of whole plant cannabis extracts that fills the gap between traditional pharmaceuticals and commonplace cannabis products. The company recently relocated all operations and production to a facility within a biotechnology campus offering state-of-the-art laboratory equipment and implemented scalable standard operating procedures (SOPs) to further drive this next generation of care.
As part of Care 2.0, Constance Therapeutics has partnered with Gridiron Cannabis Coalition to advance research into the benefits that whole plant cannabis extracts may offer athletes suffering from chronic pain, brain trauma and other sports-related injuries.
Constance Therapeutics is vertically integrated and the company’s whole plant cannabis extracts set the industry standard for quality, potency and consistency. The company’s tightly controlled, quantitatively-defined and patent-pending extraction method is based on scientific and engineering principles with each step of the extraction process precisely defined and meticulously measured according to verified practices. Constance Therapeutics is located at a Richmond, CA-based biotechnology acceleration campus, specifically designed for life science research and development companies in the biotech cluster. The company has implemented extensive SOPs and is currently implementing internationally accepted standards for pharmaceutical companies (ISO 9000) in pursuit of Good Manufacturing Practices (GMP), as well as modern clinical herbalist principles. The Constance Therapeutics laboratory features:
- Biotechnology-grade hoods for worker safety during chemical analysis and R&D testing;
- Rotary evaporator for efficient and gentle removal of solvent, allowing temperature and pressure control for optimal terpene preservation and other quality considerations;
- Chemical laboratory-grade air filtration system to remove microbial contaminants and other impurities from the air;
- State-of-the-art vacuum pumps utilized in the separation of bioactive and inert components;
- Industrial-grade, fire-safe storage equipment for proper storage, including a fire-safe freezer for ethanol storage, to prevent any explosion risk under even extraordinary conditions;
- Industry-specific vacuum ovens to optimize aesthetics.
“Care 2.0 is truly about providing physicians and their patients with expanded treatment options for conditions where previously only pharmaceuticals or nutraceuticals may have been prescribed,” said Constance Finley, founder and chief executive officer of Constance Therapeutics. “We believe cannabis should be handled the same as a traditional prescription and we are working alongside physicians to ensure patients receive the standardized formulation, individualized care and dosing instructions needed for optimal benefit. This is in stark contrast to the previous era of ‘medical marijuana,’ in which smoking the cannabis flower and using crude extractions prevented the ability to accurately determine proper dosage or efficacy. It is my hope that our science-based approach will inspire others to look at cannabis differently and see the great potential it holds.”
Constance Therapeutics’ extracts are based on modern clinical herbalist principles of synergy between plant compounds and scientific research, specifically “The Entourage Effect” theory, which shows that whole plant cannabis extracts from the female plant offer greater therapeutic benefits than isolated compounds, such as cannabidiol (CBD) only. Unlike hemp oil, whole plant cannabis extracts contain all of the naturally occurring compounds within cannabis, including tetrahydrocannabinol (THC) and CBD, as well as other cannabinoids, terpenes and flavonoids. The Entourage Effect shows that whole plant cannabis extracts from the female cannabis plant (not hemp) are more effective than isolated compounds, such as CBD (S. Ben-Shabat, with Raphael Mechoulam, 1998). Further research suggests that THC and CBD interact synergistically and that the cannabis extracts have other constituents yet to be identified that can significantly modulate the ability of THC and CBD (Ryan, Drysdale, Pertwee and Platt, 2006). Finally, the synergistic relationship between these compounds has been found to be a potential treatment for pain, inflammation, depression, anxiety, addiction, epilepsy, cancer, fungal and bacterial infections (Russo, 2011).
Constance Therapeutics works in conjunction with physicians and medical professionals to provide integrative treatment options to those suffering from serious conditions, including, but not limited to, chronic pain, Lyme disease, epilepsy and a variety of cancers, as well as autoimmune and nervous systems diseases. High-quality, standardized products that can be duplicated and scaled are essential when treating these conditions in order to determine proper dosing, as well as monitor progress and conclude efficacy. Constance Therapeutics’ ability to deliver extracts that are suitable for patients with serious conditions has enabled Care 2.0 and, in addition to a standardized, science-based extraction methodology, the company has taken several steps to achieve its industry-leading status, including:
- Sourcing all raw materials from plants with known and controlled genetics, which ensures precise duplication;
- Only using pharmaceutical-grade, certified-organic ethanol for extraction, which research has indicated to be the safest solvent for these purposes;
- Third-party testing (and routine cross-testing) of every lot of extracts at the industry’s most respected labs for cannabinoid profile (potency), pesticides, residual solvents, microbial contamination and aflatoxins.
About Constance Therapeutics
Constance Therapeutics is a vertically integrated medicinal cannabis company producing standardized and science-based whole plant cannabis extracts. The company has created a new category of whole plant cannabis extracts that provides additional treatment options and fills the gap between traditional pharmaceuticals and commonplace cannabis products. Constance Therapeutics’ extracts are produced from fully trimmed, female unfertilized cannabis sativa flowers of plants with known genetics using certified-organic, pharmaceutical-grade ethanol via a tightly-controlled, quantitatively-defined and patent-pending process that is based on scientific and engineering principles. Each lot of extracts is third party tested and routinely cross-tested in the industry’s most respected laboratories. Since 2008, the company has employed stringent, science-based processes and standards to ensure the highest quality and purity. Headquartered in Richmond, California, Constance Therapeutics’ cannabis extracts are available exclusively for therapeutic use and can only be purchased by registered California patients, in keeping with Proposition 215, and California Senate Bill 420. For further information, please visit: www.constancecbd.com.